2024
Ottaviani, Javier I; Sagi-Kiss, Virag; Schroeter, Hagen; Kuhnle, Gunter GC
In: eLife, vol. 13, pp. RP92941, 2024.
Abstract | Links | BibTeX | Tags: biomarkers, dietary assessment, epicatechin, flavanols, nitrate
@article{ottaviani2024reliance,
title = {Reliance on self-reports and estimated food composition data in nutrition research introduces significant bias that can only be addressed with biomarkers},
author = {Javier I Ottaviani and Virag Sagi-Kiss and Hagen Schroeter and Gunter GC Kuhnle},
url = {https://elifesciences.org/articles/92941},
doi = {10.7554/eLife.92941.3},
year = {2024},
date = {2024-01-01},
urldate = {2024-01-01},
journal = {eLife},
volume = {13},
pages = {RP92941},
publisher = {eLife Sciences Publications Limited},
abstract = {The chemical composition of foods is complex, variable, and dependent on many factors. This has a major impact on nutrition research as it foundationally affects our ability to adequately assess the actual intake of nutrients and other compounds. In spite of this, accurate data on nutrient intake are key for investigating the associations and causal relationships between intake, health, and disease risk at the service of developing evidence-based dietary guidance that enables improvements in population health. Here, we exemplify the importance of this challenge by investigating the impact of food content variability on nutrition research using three bioactives as model: flavan-3-ols, (–)-epicatechin, and nitrate. Our results show that common approaches aimed at addressing the high compositional variability of even the same foods impede the accurate assessment of nutrient intake generally. This suggests that the results of many nutrition studies using food composition data are potentially unreliable and carry greater limitations than commonly appreciated, consequently resulting in dietary recommendations with significant limitations and unreliable impact on public health. Thus, current challenges related to nutrient intake assessments need to be addressed and mitigated by the development of improved dietary assessment methods involving the use of nutritional biomarkers.},
keywords = {biomarkers, dietary assessment, epicatechin, flavanols, nitrate},
pubstate = {published},
tppubtype = {article}
}
The chemical composition of foods is complex, variable, and dependent on many factors. This has a major impact on nutrition research as it foundationally affects our ability to adequately assess the actual intake of nutrients and other compounds. In spite of this, accurate data on nutrient intake are key for investigating the associations and causal relationships between intake, health, and disease risk at the service of developing evidence-based dietary guidance that enables improvements in population health. Here, we exemplify the importance of this challenge by investigating the impact of food content variability on nutrition research using three bioactives as model: flavan-3-ols, (–)-epicatechin, and nitrate. Our results show that common approaches aimed at addressing the high compositional variability of even the same foods impede the accurate assessment of nutrient intake generally. This suggests that the results of many nutrition studies using food composition data are potentially unreliable and carry greater limitations than commonly appreciated, consequently resulting in dietary recommendations with significant limitations and unreliable impact on public health. Thus, current challenges related to nutrient intake assessments need to be addressed and mitigated by the development of improved dietary assessment methods involving the use of nutritional biomarkers.
2019
Breda, Simone G; Mathijs, Karen; Sági-Kiss, Virág; Kuhnle, Gunter G; Veer, Ben Van; Jones, Rena R; Sinha, Rashmi; Ward, Mary H; Kok, Theo M
Impact of high drinking water nitrate levels on the endogenous formation of apparent N-nitroso compounds in combination with meat intake in healthy volunteers Journal Article
In: Environmental Health, vol. 18, pp. 1–12, 2019.
BibTeX | Tags: cancer, nitrate
@article{van2019impact,
title = {Impact of high drinking water nitrate levels on the endogenous formation of apparent N-nitroso compounds in combination with meat intake in healthy volunteers},
author = {Simone G Breda and Karen Mathijs and Virág Sági-Kiss and Gunter G Kuhnle and Ben Van Veer and Rena R Jones and Rashmi Sinha and Mary H Ward and Theo M Kok},
year = {2019},
date = {2019-01-01},
journal = {Environmental Health},
volume = {18},
pages = {1–12},
publisher = {BioMed Central},
keywords = {cancer, nitrate},
pubstate = {published},
tppubtype = {article}
}